منابع مشابه
Sequence alignment in molecular biology
Molecular biology is becoming a computationally intense realm of contemporary science and faces some of the current grand scientific challenges. In its context, tools that identify, store, compare and analyze effectively large and growing numbers of bio-sequences are found of increasingly crucial importance. Biosequences are routinely compared or aligned, in a variety of ways, to infer common a...
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This article focuses on the key step of obtaining the best possible sequence alignment of the Query (the protein you are interested in) to the Target (a protein of known three-dimensional structure) in order to build a molecular model for molecular replacement. Common sequence-alignment methods are discussed, starting from structural alignment and then moving to pairwise, multiple and profile-p...
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Phylogenetic analysis depends crucially on the data underlying the analysis, with issues of data quality being but one aspect of the problem. A second, slightly less appreciated aspect is that of data comparability and specifically the evolutionary homology (= derivation from a common shared ancestry) of the individual characters being examined. The goal of sequence alignment is to establish th...
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To investigate how human characteristics are inherited, molecular biologists have been analyzing chemical sequences from DNA, RNA, and proteins. To facilitate this process, sequence analysis knowledge has been encoded in computer programs. However , translating human knowledge to programs is known to be problematic. Machine Learning techniques allow these systems to be generated automatically. ...
متن کاملIntroduction to Computational Biology Lecture # 4: Variations on Sequence Alignment
3 Determining the Probabilities 3.1 Determining p0(a) the probability for a single letter Biological empirical data today enables us to use the many sequences of proteins/DNA/RNA which were collected from experiments. For example, let’s look at proteins. We can simply count the number of times every amino acid appears in our protein databases. This way, we will achieve a measure of every amino ...
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ژورنال
عنوان ژورنال: Journal of Computational Biology
سال: 1998
ISSN: 1066-5277,1557-8666
DOI: 10.1089/cmb.1998.5.173